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周焕斌

      

 

 

 

周焕斌,男,籍贯湖北武汉,365美高美游戏大厅研究员、博士生导师。

2000年和2003年在华中农业大学园艺林学学院分别获蔬菜学学士和硕士学位,2007年在中国科学院遗传与发育生物学研究所获遗传学博士学位。20072015年分别在美国加州大学河滨分校植物病理与微生物学系、爱荷华州立大学遗传发育与细胞生物学系从事博士后研究工作。20154月回国,入职365美高美游戏大厅,建立基因组编辑研究组,任组长。2017年入选中国农科院“青年英才A类”,2019年入选中国农科院“农科英才领军人才B类”。目前兼任中国植物病理学会常务理事、副秘书长;中国作物学会分子育种分会理事;BMC Plant BiologyFrontiers in Genome Editing杂志Associate editor

研究组承担国家自然科学基金、中挪国际合作、国家重点研发计划专项、国家转基因重大专项等项目多项。主要从事各种植物、病原微生物基因组编辑技术和工具、以及农作物分子精准育种新方法的研究。借助其进行病原细菌致病因子水稻基因敲除突变体、以及水稻功能新种质材料的大规模创制、筛选及鉴定工作。进一步结合遗传学、分子生物学、生物化学、生物信息学等手段深入研究水稻与病原细菌互作的分子机制,发掘重要功能基因资源,加以精准修饰,培育基因组编辑水稻新材料和新品种,服务于我国水稻育种和生产。现已申请/授权国家发明专利共10项,在Cell Host & Microbe, Mol. Plant, Nucleic Acids Res., Genome Biol., Plant Biotech. J., Plant J.等国内外重要学术期刊上发表论文20多篇,其中5篇为ESI高被引论文,总引用率达1800多次。

联系方式:hbzhou@ippcaas.cn

个人网址:https://www.researchgate.net/profile/Huanbin_Zhou

 

回国后主要论文(* 通讯作者)

1. D Yan, B Ren, L Liu, F Yan, S Li, G Wang, W Sun, X Zhou & H Zhou*. High-efficiency and multiplex adenine base editing in plants using new TadA variants. Mol. Plant. 2021, https://doi.org/10.1016/j.molp.2021.02.007.

2. Y Cao, H Zhou, X Zhou & F Li*, Conferring resistance to plant RNA viruses with the CRISPR/CasRx system. Virol. Sin. 2021, https://doi.org/10.1007/s12250-020-00338-8.

3. Z Xu, Y Kuang, B Ren, D Yan, F Yan, C Spetz, W Sun, G Wang, X Zhou* & H Zhou*. SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition. Genome Biol. 2021, https://doi.org/10.1186/s13059-020-02231-9. 

4. L Liu, Y Kuang, F Yan, S Li, B Ren, G Gosavi, C Spetz, X Li, X Wang, X Zhou & H Zhou*. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of OsTubA2. Plant Biotech. J. 2021, 19(1): 5-7.

5. Y Cao, H Zhou, X Zhou*, F Li*.  Control of plant viruses by CRISPR/Cas system-mediated adaptive immunity. Front. Microbiol. 2020, 11:593700.

6. G Gosavi, F Yan, B Ren, Y Kuang, D Yan, X Zhou & H Zhou*. Applications of CRISPR technology in studying plant-pathogen interactions: overview and perspective. Phytopathol. Res. 2020, 2, 21.

7. M Wang, Z Xu, G Gosavi, B Ren, Y Cao, Y Kuang, C Zhou, C Spetz, F Yan, X Zhou & H Zhou*. Targeted base editing in rice with CRISPR/ScCas9 system. Plant Biotech. J. 2020, 18(8): 1645-1647. 

8. Y Kuang, S Li, B Ren, F Yan, C Spetz, X Li, X Zhou & H Zhou*. Base-editing-mediated artificial evolution of OsALS1 in planta to develop novel herbicide-tolerant rice germplasms. Mol. Plant 2020, 13(4): 565-572.

9. X Yang, H Zhou and X Zhou*. Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants. Sci. China. Life Sci. 2019, 62(10): 1389-1391.

10. L Zhang, Q Han, J Xiong, T Zheng, J Han, H Zhou, H Lin, Y Yin & D Zhang*.  Sumoylation of BRI1-EMS-SUPPRESSOR 1 (BES1) by the SUMO E3 ligase SIZ1 negatively regulates brassinosteroids signaling in Arabidopsis thaliana. Plant & Cell Physiol. 2019, 60(10): 2282-2292. 

11. B Ren, L Liu, S Li, Y Kuang, J Wang, D Zhang, X Zhou, H Lin* & H Zhou*.  Cas9-NG greatly expands the targeting scope of the genome-editing toolkit by recognizing NG and other atypical PAMs in rice. Mol. Plant 2019, 12(7): 1015-1026. ESI高被引论文

12. J. Long, C. Song, F. Yan, J. Zhou, H. Zhou* & B. Yang*. Non-TAL effectors from Xanthomonas oryzae pv. oryzae suppress peptidoglycan-triggered MAPK activation in rice. Front. Plant Sci. 2018, 9: 1857.

13. F. Yan, Y. Kuang, B. Ren, J Wang, D. Zhang, H. Lin, B. Yang, X. Zhou & H. Zhou*. Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice. Mol. Plant 2018, 11(4): 631-634. ESI高被引论文

14. B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, X. Zhou, H. Lin* & H. Zhou*. Improved base editor for efficiently inducing genetic variations in rice with CRISPR/Cas9-guided hyperactive hAID mutant. Mol. Plant 2018, 11(4): 623-626. ESI高被引论文

15. 旷永洁, 柳浪, 严芳, 任斌, 闫大琦, 张大伟, 林宏辉, 周焕斌*. 水稻与病原物互作中植物激素功能的研究进展. 生物技术通报. 2018, 34(2): 74-86.

16. B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, H. Lin* & H. Zhou*. A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice. Sci. China. Life Sci. 2017, 60(5): 516-519. (第二届中国科协优秀科技论文遴选计划入选论文)

17. 任斌, 严芳, 旷永洁, 李娜, 张大伟, 林宏辉*, 周焕斌*. 基于rBE3rBE4技术获得的水稻单碱基编辑植株脱靶效率和遗传稳定性. 生物工程学报. 2017, 33(10): 1776-1785.

18. 任斌, 严芳, 旷永洁, 李娜, 张大伟, 林宏辉*, 周焕斌*. 水稻靶标基因单碱基定向替换技术的建立. 中国科学:生命科学. 2017, 47(11): 1177-1185.

19. 严芳, 周焕斌*. CRISPR/Cas9技术在植物基因功能研究和新种质创制中的应用与展望. 中国科学:生命科学. 2016, 46(5): 498-513.

回国前主要论文(2015之前)

1. H. Zhou, B. Liu, D. P. Weeks, M. H. Spalding & B. Yang. Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res. 2014, 42(17): 10903-10914. ESI高被引论文

2. W. Jian, H. Zhou, H. Bi, M. Fromm, B. Yang & D. P. Weeks. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res. 2013, 41(20): e188. ESI高被引论文

3. S. Jiang, J. Yao, K. Ma, H. Zhou, J. Song, S. He & W. Ma. Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors. PLoS Pathog. 2013, 9(10): e1003715. 

4. H. Zhou, J. Lin, A. Johnson, R. L. Morgan, W. Zhong & W. Ma. Pseudomonas syringae type III effector HopZ1 targets a host enzyme to suppress isoflavone biosynthesis and promote infection in soybean. Cell Host & Microbe 2011, 9(3): 177-186. 

Commented by Andrew Bent. 2011. Pathogens Drop the Hint: Don't Forget Phytoalexin Pathways. Cell Host & Microbe. 9(3):169-70.

5. J. D. Lewis, A. Lee, W. Ma, H. Zhou, D. S. Guttman & D. Desveaux. The YopJ superfamily in plant-associated bacteria. Mol. Plant Pathol. 2011, 12(9):928-937. 

6. G. Wang, X. Wei, R. Fan, H. Zhou, X. Wang, C. Yu, L. Dong, Z. Dong, X. Wang, Z. Kang, H. Ling, Q. Shen , D. Wang & X. Zhang. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytol. 2011, 191(2): 418-431. 

7. R. L. Morgan, H. Zhou, E. Lehto, N. Nguyen, A. Bains, X. Wang & W. Ma. Catalytic domain of the diversified Pseudomonas syringae type III effector HopZ1 determines the allelic specificity in plant hosts. Mol. Microbiol. 2010, 76(2): 437-455. 

8. H. Zhou, R. L. Morgan, D. S. Guttman & W. Ma. Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems. Mol. Plant Microbe Interact. 2009, 22(2): 176-189. 

9. H. Zhou, S. Li, Z. Deng, X. Wang, T. Chen, J. Zhang, S. Chen, H. Ling, A. Zhang, D. Wang & X. Zhang. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in the wheat hypersensitive response to stripe rust fungus infection. Plant J. 2007, 52(3): 420-434. 

 

 

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